I've used Nova Launcher Prime on my Note 4 since November 2014.
I've tried many other popular launchers and I always come back to Nova in a short period of time.
I've even rooted and tried a few custom roms, including the recent CM13 (Marshmallow). I still ended up unrooting and reverting to stock software with Nova Launcher.
It allows you to keep it simple or be very complex with respect to customization.
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