So far, no major signal concerns for me (Google store Pixel 5" on VZW). Signal rarely reads all that strong (although I have seen full bars a few times on LTE). But I haven't seen it drop to 3G yet, hasn't dropped a call yet (only been on a few phone calls with it though). Wifi signal (range from access point where it stays usable) is pretty good too. Not laptop-grade, but still better than I've seen from some other phones.
Walking around my apartment, my old Samsung Stratosphere II would occasionally get some breakup in voice calls. Call quality with the pixel is perfect when walking around there (using VoLTE).
Only minor issue I've had is a couple times, it's told me that the wifi I'm connected to doesn't have internet access. But it's never failed to actually get data across when I'm using the phone and the message goes away within a couple of seconds.