I don't do anything drastic.
Location > OFF while at home
Wifi scanning > always OFF, this is a big battery killer for me
BT > OFF until I get in my car
LTE > ON, I have unlimited data so I use LTE 90% of the time usually 2-3 bars
Charging > I charge it until it's full and then I unplug it right away. My Note 5 charged all night and I did the same things as above and it would be dead by noon. I use Fast Charging.
Reboot > I reboot once a week.
Apps > I have around 100 apps, that I manually downloaded and set up, I DID NOT USE SMART SWITCH. I think this is another big battery killer.
Bloat > I used package disabler pro and froze most of the Samsung stuff except for Samsung + and calendar, most of the Sprint stuff including Flipboard, and any other installed apps that I don't use, Google play music etc.
And that's about it. I have all the other Samsung goodies turned on.
I hope this helps if I remember anything else I'll add an addendum.