I was able to load the RUU last night and had issues initially with the drivers for the phone and Windows Vista. I installed the HTC program/drivers and then ran the RUU with no issues.
It has been said before, but keep in mind if you run the RUU, everything (EVERYTHING!!!) on the phone will be removed. Apps, settings for the most part, Data, SMS, pictures if stored internal.
So far so good today...I like it a lot!
The only question I really have is what will happen when the OTA gets pushed to my phone. Will it overwrite the RUU, or just say the phone is up to date?