Love the EVO so much more than the Pre. The only things I miss are swiping apps upwards to close them (much quicker, more convenient, and makes me feel certain I've closed them). I don't like using Advanced Task Killer or whatever to be sure that apps aren't hogging my memory.
I'm still getting used to typing with the on-screen keyboard, but I think I'll be more than happy with it in the end. Other than that, this phone is simply the best out there.
There are a number of things I'm missing from the Pre, mostly related to Synergy. Something as simple as typing an email to someone on my firm's GAL takes a whole lot more effort than it did on the Pre. Also stuff like having to unlock with a full keyboard instead of that number pad on the Pre.
But I'll get used to it, more than worth it for all the bonuses you get with the EVO.