I have tried ADW, Launcher Pro, GO and the rest of them and I always end up going back to HTC Sense in its stock form. Its the most visually appealing and least laggy for me. Everytime I try a different launcher, I miss the amazing widgets and I love having my clock and weather forcast on the same screen. I have yet to find a launcher that is as good as Sense.
I'd love to have sense but I have almost stock Froyo. I usually use Go Launcher. But currently I'm trying out a beta launcher Claystone, just downloaded a couple hours ago. Its pretty nice, but obviously still in development. But I like it, its really different.
I just discovered QQlauncher.....it has a iPhone theme. I didnt like it at first because I thought u can only have 4 screens.....but I discovered you can make more. You can drag an app icon on top of another one.and it.will create a folder automatically. That is what iPhone does. I am still trying it out.
Adw EX has always been great to me on my virgin mobile "starter" droids. OFar superior to the stock launchers ! I've tried LP and go also but always go back to adw O