I too am struggling with this and we should make this a sticky as I find it very useful to get other users ideas as to what to put on different screens. Here is my current layout which I am still messing with to get the way I like it.
I'm still evolving, but for now: pages, based on position in leap view:
center: big time/weather widget, plus 8 apps based on my most used items - Gmail, Handcent, Facebook, Touiteur, People, AppBrain, Internet, and a Favorites Folder from FolderOrganizer App (which is awesome and highly recommend)
middle left: Favorites Widget full screen, but I think I am going to change and put direct call icons as they are faster to access.
middle right: A screen of setting widgets and more used apps, from left to right - Market, Voicemail, Airplane, Wi-Fi, NewsRoom, Multimedia Folder of media related apps, LED Light, 4G, Apps folder, Tools Folder of Tool related apps, Rington Widget, Bluetooth, No-Lock Widget, Battery Left Widget, Profile Widget, GPS
top left: Calendar Items: Have 4x3 Calendar Pad Widget week view, then below have calendar app and Color Note widget
top right: Sports/Extra: ScoreMobile Widget at top, then Sports Tab Widget in Middle, then Android Central Widget at bottom
bottom left: Bookmarks Widget
bottom right: HTC Music Widget, Games Folder with game related apps, and Google Search Bar, but going to rearrange this one